Nitric oxide, mitochondria and neurological disease
نویسندگان
چکیده
منابع مشابه
Nitric oxide, energy metabolism and neurological disease.
Nitric oxide, energy metabolism and neurological disease S. J. R. Heales*t§, J. E. Barkert, V. C. Stewartt, M. P. Brandt, 1. P. HargreavesV, P. Foppa*((, J. M. Land*t, J. B. Clarkt and J. P. BolahosS 'Department of Clinical Biochemistry, National Hospital for Neurology and Neurosurgery, Queen Square, London WC I N 3BG, U.K., fDepartment of Neurochemistry, Institute of Neurology, Queen Square, L...
متن کاملNitric oxide and mitochondria.
Nitric oxide (NO) and its derivatives (reactive nitrogen species) have multiple effects on mitochondria that impact on cell physiology and cell death. Mitochondria may produce and consume NO and NO stimulates mitochondrial biogenesis, apparently via cGMP upregulation of transcriptional factors. NO inhibits mitochondrial respiration via: (A) an acute and reversible inhibition of cytochrome oxida...
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Metabolic syndrome (MS) is a cluster of metabolic disorders that collectively increase the risk of cardiovascular disease. Nitric oxide (NO) plays a crucial role in the pathogeneses of MS components and is involved in different mitochondrial signaling pathways that control respiration and apoptosis. The present review summarizes the recent information regarding the interrelations of mitochondri...
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Over the past 2 to 3 decades, several phenomena have been identified that provide powerful protection against myocardial infarction and other sequelae of ischemia/reperfusion1: myocardial hibernation that is related to stunning,2 ischemic preconditioning,3 delayed or second-window ischemic preconditioning,4 ischemic postconditioning,5 and their pharmacological recruitment. Stunning and hibernat...
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Nitric oxide (NO) and its derivative, peroxynitrite (ONOO-), inhibit mitochondrial respiration, and this inhibition may contribute to both the physiological and cytotoxic actions of NO. Nanomolar concentrations of NO rapidly and reversibly inhibited cytochrome oxidase in competition with oxygen, as shown with isolated cytochrome oxidase, mitochondria, brain nerve terminals and cells. Cultured a...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Bioenergetics
سال: 1999
ISSN: 0005-2728
DOI: 10.1016/s0005-2728(98)00168-6